Cubs Depth Chart
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| Pos. | Starter | Backup | Backup | Minors | Minors | ||
| C | Geovany Soto | Henry Blanco | Koyie Hill | Tony Richie |
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| 1B | Derrek Lee | Daryle Ward |
Micah Hoffpauir | ||||
| 2B | Mike Fontenot | Mark DeRosa |
Ronny Cedeno | Bobby Scales |
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| SS | Ryan Theriot | Ronny Cedeno | Mike Fontenot |
Luis Figueroa | |||
| 3B | Aramis Ramirez | Mark DeRosa | Casey McGehee |
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| LF | Alfonso Soriano |
Reed Johnson | Mark DeRosa | Jason Dubois |
Josh Kroeger | ||
| CF | Jim Edmonds |
Reed Johnson | Felix Pie | Andre Torres | Sam Fuld |
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| RF | Mark DeRosa |
Kosuke Fukudome | Reed Johnson | Josh Kroeger | |||
| Starting Pitchers | |||||||
| 1 | Ryan Dempster (R) |
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| 2 | Rich Harden (R) | ||||||
| 3 | Carlos Zamrbanro (R) |
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| 4 | Ted Lilly (L) | ||||||
| 5 | Jason Marquis (R) | ||||||
| In Case of Emergency | Sean Marshall (L) |
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| In Case of Emergency | Jon Lieber (R) |
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| In Case of Emergency | Jeff Samardzija (R) |
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| Relief Pitchers | |||||||
| 1 | Kerry Wood (R) | ||||||
| 2 | Carlos Marmol (R) |
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| 3 | Chad Gaudin (R) | ||||||
| 4 | Jeff Samardzija (R) |
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| 5 | Bob Howry (R) | ||||||
| 6 | Neal Cotts (L) | ||||||
| 7 | Mike Wuertz (R) |
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| 8 | Angel Guzman (R) |
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| 9 | Sean Marshall (L) | ||||||
| 10 | Kevin Hart (R) | ||||||
| 11 | Randy Wells (R) | ||||||
| Disabled List | |||||||
| RP | Chad Fox (R) (ulnar nerve - 60 day) | ||||||
| RP | Rich Hill (L) (back spasms) | ||||||
| RP | Jon Lieber (R) (foot, arm - 60 day) | ||||||